Epstein-Barr Virus (HHV-4) has a dual cell tropism for human B-lymphocytes (generally non-productive infection) and epithelial cells (productive infection). There is no suitable animal host, but replication/latency has been studied extensively in transformed human cell lines. HHV-4 is widespread worldwide, with ~75% of adults infected.
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An open reading frame or ORF is a portion of an organism's genome which contains a sequence of bases that could potentially encode a protein. In a gene, ORFs are located between the start-code sequence (initiation codon) and the stop-code sequence (termination codon).
EBV Assays and Components
Monoclonal and polyclonal antibodies to proteins of the virus as well as non-structural regulatory and assembly proteins. All have been evaluated for IFA and western blot function.
Infected cell extracts, nuclear extracts, density gradient purified virus, glycoprotein fractions and more. Many are characterized with a full SDS-PAGE and western blot profile.