Human Herpes Virus 6 (HHV-6)
Human herpesvirus 6 (HHV-6) is the common collective name for Human herpesvirus 6A (HHV-6A) and Human herpesvirus 6B (HHV-6B). These closely related viruses are two of the nine herpesviruses known to have humans as their primary host.
HHV-6A and HHV-6B are double stranded DNA viruses within the betaherpesvirinae subfamily and of the genus Roseolovirus. HHV-6A and HHV-6B infects almost all of the human populations tested. HHV-6A has been described as more neurovirulent, and as such is more frequently found in patients with neuroinflammatory diseases such as multiple sclerosis.
HHV-6B primary infection is the cause of the common childhood illness exanthem subitum (also known as roseola infantum or sixth disease). Additionally, HHV-6B reactivation is common in transplant recipients, which can cause several clinical manifestations such as encephalitis, bone marrow suppression and pneumonitis.
See D K Braun, G Dominguez, P E Pellett for a review and http://hhv-6foundation.org/ for the latest in research on HHV-6.
HHV-6 Open Reading Frames
An open reading frame or ORF is a portion of an organism's genome which contains a sequence of bases that could potentially encode a protein. In a gene, ORFs are located between the start-code sequence (initiation codon) and the stop-code sequence (termination codon).
HHV-6 Assays and Components
Ready to use assays as well as components for your kits. Immunofluorescence, ELISA, western, PCR and more.
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Monoclonal and polyclonal antibodies to proteins of the virus as well as non-structural regulatory and assembly proteins. All have been evaluated for IFA and western blot function.
Infected cell extracts, nuclear extracts, density gradient purified virus, glycoprotein fractions and more. Many are characterized with a full SDS-PAGE and western blot profile.