adjuvantMicrofluidized squalene or squalane emulsions are efficient adjuvants, eliciting both humoral and cellular immune responses. Microfluidization stabilizes the emulsions and allows sterilization by terminal filtration. The emulsions are stable for years at ambient temperature and can be frozen. Antigens are added after emulsification so that conformational epitopes are not lost by denaturation and to facilitate manufacture. A Pluronic block copolymer can be added to the squalane or squalene emulsion. Soluble antigens administered in such emulsions generate cytotoxic T lymphocytes able to lyse target cells expressing the antigen in a genetically restricted fashion. Squalene or squalane emulsions without copolymers or MDP have very little toxicity and elicit potent antibody responses to several antigens in nonhuman primates. They could be used to improve a wide range of vaccines. Squalene or squalane emulsions have been administered in human cancer vaccines, with mild side effects and evidence of efficacy, in terms of both immune responses and antitumor activity.

Virusys Corporation offers four different Antimax adjuvant mixtures for enhanced antibody production. Antimax adjuvants are different combinations of squalene-based oil-in-water adjuvant, carbomer homopolymer adjuvant, and PCEP (Poly[di(sodiumcarboxylatoethylphenoxy)phosphazene]). All Antimax adjuvant mixtures have been shown to produce higher antibody titers than Freund’s Reagent.

AntiMax Reagents are supplied as ready-to-use sterile emulsions. For more information, click on the links below:

pdfAntiMax-1 - Carbomer Homopolymer adjuvant                   

AntiMax-1 Adjuvant - 10 ml

pdfAntiMax-2 - Squalene-based oil-in-water adjuvant   

AntiMax-2 Adjuvant - 10 ml

pdfAntiMax-3 - Squalene-based oil-in-water adjuvant supplemented with Carbomer Homopolymer

AntiMax-3 Adjuvant - 10 ml

pdfAntiMax-4 - Squalene-based oil-in-water adjuvant supplemented with PCEP 

AntiMax-4 Adjuvant - 10 ml